Anne Vipond and William Kelly of the Vancouver Sun compare the experience of a Seattle departure vs. Vancouver:
It’s worth taking an Alaska cruise from Seattle if you would like to spend a day or two in Seattle and would like to visit Sitka. However, if you want to see all of the Inside Passage and visit the Klondike Gold Rush town of Skagway, take your cruise from Vancouver.
There is little or no difference in cost between a round trip cruise from Seattle or one from Vancouver, although the best prices from either port are usually offered on the May sailings. According to Harvey Strydhorst of Sea Courses Cruises, good pricing is still available on Alaska cruises, comparable to the bargains that were offered last year.